3-Deazaneplanocin A |CAS:102052-95-9 Probechem Biochemicals

Chemical Structure : 3-Deazaneplanocin A

CAS No.: 102052-95-9

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3-Deazaneplanocin A (NSC 617989, 3-Deazaneplanocin, DZNep)

货号: PC-42587Not For Human Use, Lab Use Only.

3-Deazaneplanocin A (DZNep) is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.

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1 mg	￥1280	In stock
5 mg	￥2580	In stock
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25 mg		Get quote

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生物&药学活性

3-Deazaneplanocin A (DZNep) is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.
3-Deazaneplanocin A (DZNep) is more potent than 3-deazaaristeromycin.
3-Deazaneplanocin A (DZNep) induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.

物理化学性质&存储条件

分子量	262.2646
分子式	C12H14N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-

参考文献

1. Tseng CK, et al. J Med Chem. 1989 Jul;32(7):1442-6.

2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.

3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.

4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.

3-Deazaneplanocin A (NSC 617989, 3-Deazaneplanocin, DZNep)

生物&药学活性

物理化学性质&存储条件

参考文献

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3-Deazaneplanocin A (NSC 617989, 3-Deazaneplanocin, DZNep)

生物&药学活性

物理化学性质&存储条件

参考文献

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