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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Hexokinase-3-Bromopyruvic acid
3-Bromopyruvic acid

Chemical Structure : 3-Bromopyruvic acid

CAS No.: 1113-59-3

3-Bromopyruvic acid (Bromopyruvic acid;3-Bromopyruvate)

货号: PC-45777Not For Human Use, Lab Use Only.

A glycolytic inhibitor that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress.

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5 g ¥480 In stock
10 g ¥640 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A glycolytic inhibitor that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress; potentiates acetate-induced apoptosis and anti-proliferative effect in CRC cells; abrogates MUC1-mediated radiation resistance both in vitro and in vivo pancreatic cancer models, by reducing glucose flux into nucleotide biosynthetic pathways and enhancing DNA damage.

物理化学性质&存储条件

分子量 166.9581
分子式 C3H3BrO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: ≥ 32 mg/mL

Chemical Name/SMILES

Propanoic acid, 3-bromo-2-oxo-

参考文献

1. Can Z, et al. Anticancer Drugs. 2017 Aug;28(7):739-749.

2. Ferro S, et al. Oncotarget. 2016 Sep 21. doi: 10.18632/oncotarget.12156.

3. Gunda V, et al. Clin Cancer Res. 2017 Jul 18. pii: clincanres.1151.2017.

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