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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-2OH-BNPP1
2OH-BNPP1

Chemical Structure : 2OH-BNPP1

CAS No.: 833481-73-5

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2OH-BNPP1

货号: PC-21172Not For Human Use, Lab Use Only.

2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.

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10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.
2OH-BNPP1 dose-dependently impaired the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines.
2OH-BNPP1 abrogates SMAD2 phosphorylation in vivo.

物理化学性质&存储条件

分子量 297.36
分子式 C16H19N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[4-Amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]phenol

参考文献

1. Nyati S, et al. Sci Signal. 2015 Jan 6;8(358):ra1.

2. Jiang N, et al. J Exp Clin Cancer Res. 2021 Dec 1;40(1):378.

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