25CN-NBOH | 5-HT2A agonist | Probechem Biochemicals

Chemical Structure : 25CN-NBOH

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25CN-NBOH (25CN NBOH)

货号: PC-60813Not For Human Use, Lab Use Only.

25CN-NBOH is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin).

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250 mg		Get quote

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生物&药学活性

25CN-NBOH is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin).
25CN-NBOH has >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR.
25CN-NBOH exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays.
25CN-NBOH is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).

物理化学性质&存储条件

分子量	312.369
分子式	C18H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol

参考文献

1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453.

2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47.

3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375.

4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.

25CN-NBOH (25CN NBOH)

生物&药学活性

物理化学性质&存储条件

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25CN-NBOH (25CN NBOH)

生物&药学活性

物理化学性质&存储条件

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