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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-25C-NBF
25C-NBF

Chemical Structure : 25C-NBF

CAS No.: 1539266-21-1

25C-NBF (25C-NBF hydrochloride)

货号: PC-25761Not For Human Use, Lab Use Only.

25C-NBF is a potent, selective 5-HT2A agonist with binding Ki of 0.8 nM and calcium mobilization EC50 of 2.3 nM, displays 2625-, 180-, 59-fold selective over 5-HT1A, 5-HT2B and 5-HT2C receptors respectively, exhibits antidepressant effects.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

25C-NBF is a potent, selective 5-HT2A agonist with binding Ki of 0.8 nM and calcium mobilization EC50 of 2.3 nM, displays 2625-, 180-, 59-fold selective over 5-HT1A, 5-HT2B and 5-HT2C receptors respectively, exhibits antidepressant effects.

物理化学性质&存储条件

分子量 360.25
分子式 C17H20Cl2FNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzeneethanamine, 4-chloro-N-[(2-fluorophenyl)methyl]-2,5-dimethoxy-, hydrochloride (1:1)

参考文献

1. Nadal-Gratacós N, et al. Mol Psychiatry. 2025 Nov 14. doi: 10.1038/s41380-025-03341-1.

2. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.

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