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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -2-arachidonoylglycerol
2-arachidonoylglycerol

Chemical Structure : 2-arachidonoylglycerol

CAS No.: 53847-30-6

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2-arachidonoylglycerol (2-AG, 2AG)

货号: PC-26931Not For Human Use, Lab Use Only.

2-arachidonoylglycerol (2-AG) is an endocannabinoid and potent, small molecule sperm calcium channel (CatSper) inhibitor, inhibits ICatSper with IC50 of 350 nM for outward currents and 670 nM for inward currents.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

2-arachidonoylglycerol (2-AG) is an endocannabinoid and potent, small molecule sperm calcium channel (CatSper) inhibitor, inhibits ICatSper with IC50 of 350 nM for outward currents and 670 nM for inward currents.
2-arachidonoylglycerol (2-AG) inhibitss mouse ICatSper but with less efficacy than it inhibits human ICatSper.

物理化学性质&存储条件

分子量 378.55
分子式 C23H38O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5Z,8Z,11Z,14Z)-1,3-Dihydroxypropan-2-yl icosa-5,8,11,14-tetraenoate

参考文献

1. Edwards M, et al. Hum Reprod. 2026 May 29:deag085.

2. Miller MR, et al. Science. 2016 Apr 29;352(6285):555-9.

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