2-TCPA

Chemical Structure : 2-TCPA

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货号: PC-38907Not For Human Use, Lab Use Only.

2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM.

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生物&药学活性

2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM.
2-TCPA efficiently inhibited RelA deamidation in Caco-2 cells expressing Nsp9.
2-TCPA increased the expression of NF-κB–responsive genes, such as IL-6, IL-8, and CCL5, in a dose-dependent manner in HEK293T cells infected with Sendai virus.
2-TCPA also greatly elevated TNFA, NFKB1A, and CCL5 expression in SARS-CoV-2-infected Calu-3 cells.
2-TCPA potently inhibited SARS-CoV-2 replication in a dose-dependent manner in NHBE.
2-TCPA inhibits SARS-CoV-2 replication in mouse models, reduced SARS-CoV-2 load in the lung, reduced viral RNA content and reduced N protein expression in both alveoli and bronchioli areas.

物理化学性质&存储条件

分子量	153.159
分子式	C5H3N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-cyanothiazole-2-carboxamide

参考文献

1. Chao Qin, et al. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2122897119.

2-TCPA

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2-TCPA

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