2-PCCA hydrochloride | GPR88 agonist | Probechem Biochemicals

Chemical Structure : 2-PCCA hydrochloride

CAS No.: 1609563-71-4

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2-PCCA hydrochloride ((1R,2R)-2-PCCA hydrochloride)

货号: PC-22286Not For Human Use, Lab Use Only.

2-PCCA hydrochloride is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.

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生物&药学活性

2-PCCA hydrochloride is a potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
2-PCCA inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway.
2-PCCA dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine.
2-PCCA does not alter the behavioral effects of methamphetamine in rats alone.

物理化学性质&存储条件

分子量	528.56
分子式	C30H39Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-N-((2S,3S)-2-Amino-3-methylpentyl)-N-(4'-propyl-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide dihydrochloride

参考文献

1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7.

2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.

2-PCCA hydrochloride ((1R,2R)-2-PCCA hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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2-PCCA hydrochloride ((1R,2R)-2-PCCA hydrochloride)

生物&药学活性

物理化学性质&存储条件

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