2-Cl-IB-MECA |CAS:163042-96-4 Probechem Biochemicals

Chemical Structure : 2-Cl-IB-MECA

CAS No.: 163042-96-4

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2-Cl-IB-MECA (Cl-IB-MECA;CF-102;Namodenoson)

货号: PC-43007Not For Human Use, Lab Use Only.

2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor (A3AR) agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor (A3AR) agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
2-Cl-IB-MECA also displays 46,000-fold selectivity versus the Na(+)-independent adenosine transporter.
2-Cl-IB-MECA inhibits adenylate cyclase via rat A3 receptors in CHO cells (IC50=67 nM).
2-Cl-IB-MECA induces apoptosis in HL-60 cells at concentrations of <30 uM, significantly induced Ca(2+) release from intracellular Ca(2+) pools followed by Ca(2+) influx.
2-Cl-IB-MECA increases plasma histamine concentrations in conscious rats.

物理化学性质&存储条件

分子量	544.7308
分子式	C18H18ClIN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	β-D-Ribofuranuronamide, 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-

参考文献

1. Van Schaick EA, et al. Eur J Pharmacol. 1996 Jul 25;308(3):311-4.

2. Kim HO, et al. J Med Chem. 1994 Oct 14;37(21):3614-21.

3. Kohno Y, et al. Biochem Biophys Res Commun. 1996 Feb 27;219(3):904-10.

4. Dunwiddie TV, et al. J Neurosci. 1997 Jan 15;17(2):607-14.

2-Cl-IB-MECA (Cl-IB-MECA;CF-102;Namodenoson)

生物&药学活性

物理化学性质&存储条件

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2-Cl-IB-MECA (Cl-IB-MECA;CF-102;Namodenoson)

生物&药学活性

物理化学性质&存储条件

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