2-AAPA

Chemical Structure : 2-AAPA

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货号: PC-24311Not For Human Use, Lab Use Only.

2-AAPA is an irreversible inhibitor of glutathione reductase (GR) with Ki of 56 uM (yeast GR), induces ferroptosis in A549 cells, induces microtubule S-glutathionylation.

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生物&药学活性

2-AAPA is an irreversible inhibitor of glutathione reductase (GR) with Ki of 56 uM (yeast GR), induces ferroptosis in A549 cells, induces microtubule S-glutathionylation.
2-AAPA shows no inhibition against glutamylcysteine synthetase, glutathione synthetase, catalase, and superoxide dismutase, but minimal inhibition against glutathione S-transferase and glutathione peroxidase.
2-AAPA (0.1 mM) produced 97% GR inhibition, 25% GSH reduction, and a 5-fold increase in GSSG in 20 min, in CV-1 cells.

物理化学性质&存储条件

分子量	518.64
分子式	C18H22N4O6S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	S,S'-[1,4-Phenylenebis(iminocarbonothioyl)]bis[N-acetyl-L-cysteine]

参考文献

1. Seefeldt T, et al. J Biol Chem. 2009 Jan 30;284(5):2729-2737.

2. Chen W, et al. BMC Cancer. 2012 Jun 15;12:245.

2-AAPA

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物理化学性质&存储条件

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2-AAPA

生物&药学活性

物理化学性质&存储条件

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