1E7-03 |CAS:1565845-92-2 Probechem Biochemicals

Chemical Structure : 1E7-03

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1E7-03

货号: PC-35229Not For Human Use, Lab Use Only.

1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).

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生物&药学活性

1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM)。
1E7-03 disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice.
1E7-03 inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46.

物理化学性质&存储条件

分子量	503.555
分子式	C28H29N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-ethylureido)-1-oxopropan-2-yl (Z)-3-(3,4-dimethoxybenzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylate

参考文献

1. Carey BD, et al. J Virol. 2018 May 16. pii: JVI.02068-17.

2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38.

3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75.

4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769.

1E7-03

生物&药学活性

物理化学性质&存储条件

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1E7-03

生物&药学活性

物理化学性质&存储条件

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