17-AAG (Tanespimycin) | HSP90 inhibitor | Probechem Biochemicals

Chemical Structure : 17-AAG

CAS No.: 75747-14-7

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17-AAG (Tanespimycin, NSC 330507, CP 127374, 17AAG)

货号: PC-42457Not For Human Use, Lab Use Only.

17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2180	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.
17-AAG induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells.
17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor.
17-AAG inhibits prostate cancer xenografts growth in mice.

物理化学性质&存储条件

分子量	585.6884
分子式	C31H43N3O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 55 mg/mL
Chemical Name/SMILES	Geldanamycin, 17-demethoxy-17-(2-propenylamino)-

参考文献

1. Kamal A, et al. Nature. 2003 Sep 25;425(6956):407-10.

2. Solit DB, et al. Clin Cancer Res. 2002 May;8(5):986-93.

3. Nimmanapalli R, et al.Cancer Res. 2001 Mar 1;61(5):1799-804.

17-AAG (Tanespimycin, NSC 330507, CP 127374, 17AAG)

生物&药学活性

物理化学性质&存储条件

参考文献

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17-AAG (Tanespimycin, NSC 330507, CP 127374, 17AAG)

生物&药学活性

物理化学性质&存储条件

参考文献

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