16F16 | PDI inhibitor | Probechem Biochemicals

Chemical Structure : 16F16

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16F16 (PDI inhibitor 16F16)

货号: PC-61520Not For Human Use, Lab Use Only.

16F16 is a small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins.

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100 mg		Get quote

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生物&药学活性

16F16 is a small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins.
16F16 protects rat neurons from cell death triggered by Aβ peptide.
16F16 reduces Zika virus replication in vitro but demonstrates notable toxicity.
16F16 inhibits CHIKV E1-induced cell-cell fusion.

物理化学性质&存储条件

分子量	320.77
分子式	C16H17ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

参考文献

1. Hoffstrom BG, et al. Nat Chem Biol. 2010 Dec;6(12):900-6.

2. Langsjoen RM, et al. Antiviral Res. 2017 Jul;143:246-251.

3. Goodale LF, et al. Oncotarget. 2017 May 16;8(20):32419-32432.

16F16 (PDI inhibitor 16F16)

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16F16 (PDI inhibitor 16F16)

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