16D10

Chemical Structure : 16D10

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货号: PC-26535Not For Human Use, Lab Use Only.

16D10 is a small molecule inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 1.5 uM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region.

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生物&药学活性

16D10 is a small molecule inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 1.5 uM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region.
16D10 suppresses TSLP production in mouse and human keratinocytes and in the ovalbumin-induced air-pouch-type inflammation model of mice without inhibiting Tumor necrosis factor-alpha (TNF-α) production.
16D10 suppresses allergen-induced IgE production in mice.

物理化学性质&存储条件

分子量	413.47
分子式	C23H27NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-(3-(2,5-dimethoxyphenyl)acryloyl)-4,5-dimethoxyphenethyl)acetamide

参考文献

1. Ryosuke Segawa, et al. Biochem Pharmacol. 2021 Dec:194:114819.

16D10

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16D10

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