164B8

Chemical Structure : 164B8

加入收藏

货号: PC-26206Not For Human Use, Lab Use Only.

164B8 is a highly potent, covalent Pin1 inhibitor / degrader with IC50 of 4.65 nM, reacts with the Pin1 active-site residue Cys113, effectively induces Pin1 degradation both in cell and in vivo.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

164B8 is a highly potent, covalent Pin1 inhibitor / degrader with IC50 of 4.65 nM, reacts with the Pin1 active-site residue Cys113, effectively induces Pin1 degradation both in cell and in vivo.
164B8 (5 uM) induces duration of Pin1 degradation approximately 50% after 48 h in BxPC3 and KPC cells.
164B8 inhibits cell viability of MIA PaCa-2 cells and KPC cell lines with EC50 of 8.4 uM and 5.3 uM respectively.
164B8 (30 mg/kg, 60 mg/kg) caused significant, dose-dependent reduction in tumor burden in murine model of metastatic pancreatic cancer.

物理化学性质&存储条件

分子量	625.55
分子式	C31H34Cl2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-1-((S)-3-(6-chloro-1H-indol-3-yl)-2-(2-chloroacetamido)propanoyl)piperidine-2-carboxamide

参考文献

1. Giulia Alboreggia, et al. Mol Ther Oncol. 2025 Nov 1;33(4):201078.

2. Patent US20250296955 A1.

164B8

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

164B8

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.