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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Nitric Oxide Synthase (NOS)-1400W dihydrochloride
1400W dihydrochloride

Chemical Structure : 1400W dihydrochloride

CAS No.: 214358-33-5

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1400W dihydrochloride (iNOS inhibitor)

货号: PC-70228Not For Human Use, Lab Use Only.

1400W dihydrochloride is a potent, selective inhibitor of iNOS with Ki of 7 nM.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

1400W dihydrochloride is a potent, selective inhibitor of iNOS with Ki of 7 nM.
1400W dihydrochloride dispalys >250-fold selectivity over nNOS, and eNOS.
1400W dihydrochloride blocks AGT depletion and rescues the repair of mutagenic O6-ethyldeoxyguanosines following DEN challenge in livers of GSNOR-deficient (GSNOR(-/-)) mice.

物理化学性质&存储条件

分子量 250.2
分子式 C10H15N3 • 2HCl
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(aminomethyl)benzyl)acetimidamide

参考文献

1. Garvey EP, et al. J Biol Chem. 1997 Feb 21;272(8):4959-63.

2. Inano H, et al. Nitric Oxide. 2005 Feb;12(1):15-20.

3. Tang CH, et al. Cancer Res. 2013 May 1;73(9):2897-904.

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