14-3-3 inhibitor BV02 | 14-3-3 inhibitor | Probechem Biochemicals

Chemical Structure : 14-3-3 inhibitor BV02

CAS No.: 302602-92-2

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14-3-3 inhibitor BV02 (BV02)

货号: PC-61231Not For Human Use, Lab Use Only.

14-3-3 inhibitor BV02 is a novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
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生物&药学活性

14-3-3 inhibitor BV02 is a novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.
BV02 induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively.
BV02 promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels.
BV02 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib.

物理化学性质&存储条件

分子量	395.371
分子式	C20H17N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbamoyl)terephthalic acid

参考文献

1. Mancini M, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604.

2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug;33(16):3214-26.

3. Gómez-Suárez M, et al. Cell Death Differ. 2016 Jun;23(6):1060-72.

4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898.

14-3-3 inhibitor BV02 (BV02)

生物&药学活性

物理化学性质&存储条件

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14-3-3 inhibitor BV02 (BV02)

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