103D5R | HIF-1α inhibitor | Probechem Biochemicals

Chemical Structure : 103D5R

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103D5R (HIF-1α inhibitor)

货号: PC-62894Not For Human Use, Lab Use Only.

103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
103D5R shows cell proliferation under normoxia in LN229 cell with IC50 of 26 uM, markedly decreases HIF-1α protein synthesis induced by hypoxia or cobaltous ions in a dose- and time-dependent manner.
103D5R inhibits phosphorylation of Akt, SAPK/JNK and Erk1/2, prevents the activation of HIF-1 target genes under hypoxia such as VEGF and Glut-1.

物理化学性质&存储条件

分子量	335.407
分子式	C20H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl]-1H-imidazo[4,5-b]pyridine

参考文献

1. Tan C, et al. Cancer Res. 2005 Jan 15;65(2):605-12.

2. Belozerov VE, et al. Anticancer Drugs. 2005 Oct;16(9):901-9.