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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-10074-A4
10074-A4

Chemical Structure : 10074-A4

CAS No.: 312631-87-1

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10074-A4

货号: PC-21473Not For Human Use, Lab Use Only.

10074-A4 is a specific small molecule inhibitor of c-Myc370-409 with binding Kd of 36.3 uM.

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5 mg ￥1880 In stock
10 mg ￥2880 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

10074-A4 is a specific small molecule inhibitor of c-Myc 370-409 with binding Kd of 36.3 uM.
10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4.
10074-A4 arrests the cell cycle at the S-phase, shows inhibitory activity of HL-60 cells with IC50 of 15.1 uM.

物理化学性质&存储条件

分子量 409.28
分子式 C18H14Cl2N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione

参考文献

1. Chen Yu, et al. Sci Rep. 2016 Mar 2;6:22298.

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