10-NCP |CAS:925681-41-0 Probechem Biochemicals

Chemical Structure : 10-NCP

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10-NCP (10-DEBC;NCP)

货号: PC-62208Not For Human Use, Lab Use Only.

10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM).

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生物&药学活性

10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM).
10-NCP displays minimal effect on PI3K, PDK1, or SGK1.
10-NCP blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppresses growth of Rh1, Rh18, and Rh30 cells (IC50=2-5 uM).

物理化学性质&存储条件

分子量	381.341
分子式	C20H26Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

参考文献

1. Barmada SJ, et al. Nat Chem Biol. 2014 Aug;10(8):677-85.

2. Tsvetkov AS, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16982-7.

3. Thimmaiah KN, et al. J Biol Chem. 2005 Sep 9;280(36):31924-35.

10-NCP (10-DEBC;NCP)

生物&药学活性

物理化学性质&存储条件

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10-NCP (10-DEBC;NCP)

生物&药学活性

物理化学性质&存储条件

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