1.21S9N

Chemical Structure : 1.21S9N

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货号: PC-26484Not For Human Use, Lab Use Only.

1.21S9N is a potent, dual HIF-1/2 inhibitor with MST Kd of 2.2 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 72 nM and 128 nM in immunoblot assays.

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生物&药学活性

1.21S9N is a potent, dual HIF-1/2 inhibitor with MST Kd of 2.2 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 72 nM and 128 nM in immunoblot assays.
1.21S9N (40 mg/kg BID) showed superior activity against breast and colorectal cancer models compared within PT2385, inhibited hypoxia-induced adrenomedullin (Adm) mRNA expression.

物理化学性质&存储条件

分子量	510.76
分子式	C27H38N6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(propane-1,3-diyl)bis(N-(pyridine-4-ylmethyl)piperidine-1-carbothioamide)

参考文献

1. Salman S, et al. J Exp Med. 2026 May 4;223(5):e20251009.

1.21S9N

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物理化学性质&存储条件

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1.21S9N

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物理化学性质&存储条件

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