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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Src-1-NM-PP1
1-NM-PP1

Chemical Structure : 1-NM-PP1

CAS No.: 221244-14-0

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1-NM-PP1 (1NM-PP1)

货号: PC-26293Not For Human Use, Lab Use Only.

1-NM-PP1 is a cell-permeable PP1 analog and potent Src family kinases inhibitor with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively, also inhibits PKD with IC50 of 398 nM (PKD2) and analog-sensitive CRK9 (CRK9AS).

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

1-NM-PP1 is a cell-permeable PP1 analog and potent Src family kinases inhibitor with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively, also inhibits PKD with IC50 of 398 nM (PKD2) and analog-sensitive CRK9 (CRK9AS).

物理化学性质&存储条件

分子量 331.42
分子式 C20H21N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(tert-butyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

参考文献

1. Goyard S, et al. Mol Biol Cell. 2008 May;19(5):2251-66.

2. Plank M, et al. Mol Biol Cell. 2024 Apr 1;35(4):ar60.

3. Bishop AC, et al. Nature. 2000 Sep 21;407(6802):395-401.

4. Gosavi U, et al. Mol Microbiol. 2020 Jun;113(6):1225-1239.

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