1-Azakenpaullone | GSK3β inhibitor | Probechem Biochemicals

Chemical Structure : 1-Azakenpaullone

CAS No.: 676596-65-9

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1-Azakenpaullone (1-Akp)

货号: PC-63153Not For Human Use, Lab Use Only.

1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM).
1-Azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells.

物理化学性质&存储条件

分子量	328.169
分子式	C15H10BrN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one

参考文献

1. Kunick C, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.

2. Mishra R, et al. J Biol Chem. 2007 Oct 19;282(42):30393-405.

3. Mfopou JK, et al. Stem Cell Res. 2014 Jan;12(1):166-77.

4. Liu H, et al. Diabetes. 2009 Mar;58(3):663-72.

1-Azakenpaullone (1-Akp)

生物&药学活性

物理化学性质&存储条件

参考文献

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1-Azakenpaullone (1-Akp)

生物&药学活性

物理化学性质&存储条件

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