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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-1’-cyanocytidine
1’-cyanocytidine

Chemical Structure : 1’-cyanocytidine

CAS No.: 1402821-68-4

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1’-cyanocytidine

货号: PC-28371Not For Human Use, Lab Use Only.

1'-cyanocytidine (CNC) is a nontoxic, next-generation nucleoside analog that displays submicromolar inhibition of SARS-CoV-2 replication with EC50 of 0.6-2.1 uM, targeting the viral RNA-dependent RNA polymerase (RdRp).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

1'-cyanocytidine (CNC) is a nontoxic, next-generation nucleoside analog that displays submicromolar inhibition of SARS-CoV-2 replication with EC50 of 0.6-2.1 uM, targeting the viral RNA-dependent RNA polymerase (RdRp).

物理化学性质&存储条件

分子量 268.23
分子式 C10H12N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

参考文献

1. Amblard F, et al. Sci Adv. 2025 Oct 3;11(40):eadz5913.

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