(±)VK4-40 | D3R agonist | Probechem Biochemicals

Chemical Structure : (±)VK4-40

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(±)VK4-40 ((±) VK4-40)

货号: PC-47102Not For Human Use, Lab Use Only.

(±)VK4-40 is a highly selective and metabolically stable D3 partial agonist, shows high affinity for D3 receptor (Ki=0.35 nM) and high selectivity for D3 over the D2 receptor.

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生物&药学活性

(±)VK4-40 is a highly selective and metabolically stable D3 partial agonist, shows high affinity for D3 receptor (Ki=0.35 nM) and high selectivity for D3 over the D2 receptor.
(±)VK4‐40 inhibits cocaine self‐administration andcocaine‐primed reinstatement of drug seeking but does not inhibit sucrose self‐administration.
(±)VK4‐40 also inhibits optogenetic brain‐stimulation reward and cocaine‐enhanced brain‐stimulation reward.

物理化学性质&存储条件

分子量	454.999
分子式	C25H31ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(2-chloro-3-ethylphenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide

参考文献

1. Vivek Kumar, et al. J Med Chem. 2016 Aug 25;59(16):7634-50.

2. Jordan CJ, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):602-614.

3. Jordan CJ, et al. Neuropharmacology. 2019 Nov 1;158:107597.

(±)VK4-40 ((±) VK4-40)

生物&药学活性

物理化学性质&存储条件

参考文献

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(±)VK4-40 ((±) VK4-40)

生物&药学活性

物理化学性质&存储条件

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