(Z)-4-Hydroxytamoxifen |CAS:68047-06-3 Probechem Biochemicals

Chemical Structure : (Z)-4-Hydroxytamoxifen

CAS No.: 68047-06-3

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(Z)-4-Hydroxytamoxifen (trans-4-Hydroxytamoxifen)

货号: PC-45096Not For Human Use, Lab Use Only.

A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.

规格	价格	库存
5 mg	￥800	In stock
10 mg	￥1120	In stock
25 mg	￥2400	In stock
50 mg	￥4400	In stock

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生物&药学活性

A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; shows a 100-fold increased affinity for ER and approximately 100-times more potent than trans-tamoxifen in suppressing cell growth and plasminogen activator activity.

物理化学性质&存储条件

分子量	387.5139
分子式	C26H29NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-

参考文献

1. Katzenellenbogen BS, et al. Cancer Res. 1984 Jan;44(1):112-9.

2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.

3. Crewe HK, et al. Drug Metab Dispos. 2002 Aug;30(8):869-74.

(Z)-4-Hydroxytamoxifen (trans-4-Hydroxytamoxifen)

生物&药学活性

物理化学性质&存储条件

参考文献

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(Z)-4-Hydroxytamoxifen (trans-4-Hydroxytamoxifen)

生物&药学活性

物理化学性质&存储条件

参考文献

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