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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-(S)-PBMC
(S)-PBMC

Chemical Structure : (S)-PBMC

CAS No.: 1352138-54-5

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(S)-PBMC (PBMC)

货号: PC-60788Not For Human Use, Lab Use Only.

(S)-PBMC is a potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    (S)-PBMC is a potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8).
    (S)-PBMC antagonizes in vitro activation of human and guinea-pig TRPM8 and reverses menthol and cold-induced facilitation of the micturition reflex at plasma concentrations consistent with in vitro potencies.

    物理化学性质&存储条件

    分子量 434.536
    分子式 C26H30N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-phenylethyl (2-aminoethyl)(4-(benzyloxy)-3-methoxybenzyl)carbamate

    参考文献

    1. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.

    2. Knowlton WM, et al. PLoS One. 2011;6(9):e25894.

    3. Sałat K, et al. Curr Med Chem. 2013;20(11):1409-36.

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