(S)-FQI1 | LSF inhibitor | Probechem Biochemicals

Chemical Structure : (S)-FQI1

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(S)-FQI1 ((S)-FQI 1)

货号: PC-62024Not For Human Use, Lab Use Only.

(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.

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生物&药学活性

(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.
(S)-FQI1 inhibits LSF DNA-binding activity both in vitro, also exhibits antiproliferative activity in multiple cell lines, NIH 3T3, HeLa S3, and A549 cells with GI50 of 0.82, 0.30, and 1.2 uM, respectively.
(S)-FQI1 rapidly induces cell death in QGY-7703 liver cancer cell lines.

物理化学性质&存储条件

分子量	311.33
分子式	C18H17NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

参考文献

1. Grant TJ, et al. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4503-8.

(S)-FQI1 ((S)-FQI 1)

生物&药学活性

物理化学性质&存储条件

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(S)-FQI1 ((S)-FQI 1)

生物&药学活性

物理化学性质&存储条件

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