(S)-3,4-DCPG | mGluR8 agonist | Probechem Biochemicals

Chemical Structure : (S)-3,4-DCPG

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(S)-3,4-DCPG (S-3,4-DCPG, (S)-3,4-Dicarboxyphenylglycine)

货号: PC-22229Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
(S)-3,4-DCPG depressed the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) giving a biphasic concentration-response curve showing EC50 of 1.3 uM.
(S)-3,4-DCPG activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
(S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus in mice.

物理化学性质&存储条件

分子量	239.18
分子式	C10H9NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(Amino(carboxy)methyl)phthalic acid

参考文献

1. Thomas NK, et al. Neuropharmacology. 2001 Mar;40(3):311-8.

2. Linden AM,et al. Neuropharmacology. 2003 Sep;45(4):473-83.

(S)-3,4-DCPG (S-3,4-DCPG, (S)-3,4-Dicarboxyphenylglycine)

生物&药学活性

物理化学性质&存储条件

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(S)-3,4-DCPG (S-3,4-DCPG, (S)-3,4-Dicarboxyphenylglycine)

生物&药学活性

物理化学性质&存储条件

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