(S)-(-)-DQP-997-74

Chemical Structure : (S)-(-)-DQP-997-74

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货号: PC-21030Not For Human Use, Lab Use Only.

(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors.

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生物&药学活性

(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors.
(S)-(-)-DQP-997-74 shows no activity at AMPA, GABA, glycine, nicotinic, or purinergic P2X receptors at 1 uM.
(S)-(-)-DQP-997-74 shows a time-dependent enhancement of inhibitory actions at GluN2C- and GluN2D-containing NMDARs in the presence of the agonist glutamate.
(S)-(-)-DQP-997-74 significantly reduced the number of epileptic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy.

物理化学性质&存储条件

分子量	570.37
分子式	C28H19Cl2F2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(5-(4-chlorophenyl)-3-(4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-3,3-difluoro-4-oxobutanoic acid

参考文献

1. Michael P. D'Erasmo, et al. ACS Chemical Neuroscience. August 11, 2023.

(S)-(-)-DQP-997-74

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(S)-(-)-DQP-997-74

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