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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-(RS)-G12Di-1
(RS)-G12Di-1

Chemical Structure : (RS)-G12Di-1

CAS No.:

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(RS)-G12Di-1

货号: PC-24256Not For Human Use, Lab Use Only.

(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D.
(RS)-G12Di-1 showed markedly reduced reactivity with K-Ras-G12E•GDP.
(RS)-G12Di-1 also active against the GppNHp-bound K-Ras-G12D.
The covalent modification of Asp12 by (RS)-G12Di-1 stabilized both K-Ras-G12D•GDP and K-Ras-G12D•GppNHp toward thermal denaturation (ΔTm = +10.3 °C and +2.5 °C, respectively).

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Zheng Q, et al. Nat Chem Biol. 2024 Sep;20(9):1114-1122.

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