(R,S)-MNF | GPR55 inhibitor | Probechem Biochemicals

Chemical Structure : (R,S)-MNF

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(R,S)-MNF ((R,S')-MNF)

货号: PC-38003Not For Human Use, Lab Use Only.

(R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).

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生物&药学活性

(R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).
(R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2.
(R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells.
(R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling.
(R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model.

物理化学性质&存储条件

分子量	367.445
分子式	C22H25NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((R)-1-hydroxy-2-(((S)-1-(4-methoxynaphthalen-1-yl)propan-2-yl)amino)ethyl)benzene-1,3-diol

参考文献

1. Artur Wnorowski, et al. Sci Rep. 2022 Mar 7;12(1):3618.

(R,S)-MNF ((R,S')-MNF)

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(R,S)-MNF ((R,S')-MNF)

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物理化学性质&存储条件

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