(R)-WAC-224

Chemical Structure : (R)-WAC-224

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货号: PC-24552Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

(R)-WAC-224 is an anticancer quinolone taht demonstrates cell growth inhibition against venetoclax-resistant AML cells (MOLM-13, IC50=0.02 uM), directly inhibits topoisomerase-2 (Topo-II) and exhibits antileukemic effects both in vitro and in vivo.
(R)-WAC-224 reduced MCL-1 expression in parental and VEN-resistant AML cells
The combination of (R)-WAC-224 and venetoclax strongly induced cell apoptosis through DNA damage.
(R)-WAC-224 downregulated MCL-1 levels via the cleaved caspase-3 pathway in parental and venetoclax-resistant AML cells.
Azacitidine, venetoclax, and (R)-WAC 224 demonstrated antitumor effects against both parental MV4-11 and venetoclax-resistant MV4-11 cells in a xenograft mouse model.

物理化学性质&存储条件

分子量	483.54
分子式	C23H25N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-7-[3-[[[[(2R)-tetrahydro-2H-pyran-2-yl]methyl]amino]carbonyl]-1-azetidinyl]-1-(2-thiazolyl)-

参考文献

1. Mino T, et al. Invest New Drugs. 2023 Oct;41(5):751-760.

2. Rania Alaaeldin, et al. Molecules. 2022 Nov 17;27(22):7993.

(R)-WAC-224

生物&药学活性

物理化学性质&存储条件

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(R)-WAC-224

生物&药学活性

物理化学性质&存储条件

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