(R)-STU104 | TAK1-MKK3 PPI inhibitor | Probechem Biochemicals

Chemical Structure : (R)-STU104

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(R)-STU104 (TAK1-MKK3 inhibitor)

货号: PC-38495Not For Human Use, Lab Use Only.

(R)-STU104 is a potent, first-in-class TAK1-MKK3 porotein-protein interaction (PPI) inhibitor with SPR Kd of 71 nM for binding MKK3, disrupting the TAK1 phosphorylating MKK3.

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生物&药学活性

(R)-STU104 is a potent, first-in-class TAK1-MKK3 porotein-protein interaction (PPI) inhibitor with SPR Kd of 71 nM for binding MKK3, disrupting the TAK1 phosphorylating MKK3.
(R)-STU104 exhibited the potent inhibitory activity on TNF-α production on RAW264.7 cells with IC50 of 0.58 uM, suppressed the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways.
(R)-STU104 demonstrated remarkable dose-effect relationships on both acute and chronic mouse ulcerative colitis (UC) models.
(R)-STU104 showed better anti-UC efficacy in vivo at 10 mg/kg/d than mesalazine at the dose of 50 mg/kg/d.

物理化学性质&存储条件

分子量	298.338
分子式	C18H18O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4,6-dimethoxy-3-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one

参考文献

1. Mei-Lin Tang, et al. J Med Chem. 2022 Apr 20. doi: 10.1021/acs.jmedchem.1c02198.

(R)-STU104 (TAK1-MKK3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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(R)-STU104 (TAK1-MKK3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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