(R)-SKBG-1

Chemical Structure : (R)-SKBG-1

CAS No.: 2955634-67-8

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货号: PC-20048Not For Human Use, Lab Use Only.

(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
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生物&药学活性

(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.
(R)-SKBG-1 promoted NONO accumulation in nuclear foci and stabilized NONO-RNA interactions.
Reintroduction of wild-type NONO, but not a C145S mutant, restored (R)-SKBG-1 sensitivity in NONO-disrupted cells.

物理化学性质&存储条件

分子量	495.98
分子式	C22H26ClN3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(2-chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide

参考文献

1. Kathman SG, et al. Nat Chem Biol. 2023 Mar 2. doi: 10.1038/s41589-023-01270-0.

(R)-SKBG-1

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(R)-SKBG-1

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