(R)-OF-NB1

Chemical Structure : (R)-OF-NB1

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货号: PC-21397Not For Human Use, Lab Use Only.

(R)-OF-NB1 is a small molecule splice variant GluN2B-selective NMDAR antagonist with IC50 of 675 nM and 97 nM for F-NB1 for splice variant containing exon 5 and GluN1-1a in X. laevis oocytes.

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生物&药学活性

(R)-OF-NB1 is a small molecule splice variant GluN2B-selective NMDAR antagonist with IC50 of 675 nM and 97 nM for F-NB1 for splice variant containing exon 5 and GluN1-1a in X. laevis oocytes.
(R)-OF-NB1 clearly discriminates the two splice variants, GluN1-1a and GluN1-1b.

物理化学性质&存储条件

分子量	329.42
分子式	C20H24FNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-(2-fluorophenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-1,7-diol

参考文献

1. Ritter N, et al. Mol Neurobiol. 2023 Dec;60(12):7238-7252.

(R)-OF-NB1

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(R)-OF-NB1

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