(R)-HZ05 |CAS:2097360-28-4 Probechem Biochemicals

Chemical Structure : (R)-HZ05

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(R)-HZ05 (DHODH inhibitor (R)-HZ05)

货号: PC-63262Not For Human Use, Lab Use Only.

(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..

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生物&药学活性

(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.

物理化学性质&存储条件

分子量	380.423
分子式	C21H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide

参考文献

1. Ladds MJGW, et al. Nat Commun. 2018 Mar 16;9(1):1107.

(R)-HZ05 (DHODH inhibitor (R)-HZ05)

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(R)-HZ05 (DHODH inhibitor (R)-HZ05)

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