(R)-GNE-140 |CAS:2003234-63-5 Probechem Biochemicals

Chemical Structure : (R)-GNE-140

CAS No.: 2003234-63-5

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(R)-GNE-140 (GNE-140;GNE 140;GNE140)

货号: PC-42246Not For Human Use, Lab Use Only.

(R)-GNE-140 (GNE-140) is a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively.

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5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
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生物&药学活性

(R)-GNE-140 (GNE-140) is a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively。
GNE-140 displays no inhibition on malate MDH-1, MDH-2 (IC50>10 uM for both enzymes), and no appreciable inhibition against a panel of 301 kinases (<50% inhibition at 1 uM).
GNE-140 perturbs glycolysis and inhibits proliferation in MIA PaCa-2 cells (IC50=0.43 uM), decreases glucose uptake (IC50=0.47 uM).
Pancreatic cell lines that utilize oxidative OXPHOS rather than glycolysis are inherently resistant to GNE-140, which can be resensitized to GNE-140 with the OXPHOS inhibitor phenformin.

物理化学性质&存储条件

分子量	499.0447
分子式	C25H23ClN2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

参考文献

1. Boudreau A, et al. Nat Chem Biol. 2016 Oct;12(10):779-86.

(R)-GNE-140 (GNE-140;GNE 140;GNE140)

生物&药学活性

物理化学性质&存储条件

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(R)-GNE-140 (GNE-140;GNE 140;GNE140)

生物&药学活性

物理化学性质&存储条件

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