(R)-AS-1 | EAAT2 PAM | Probechem Biochemicals

Chemical Structure : (R)-AS-1

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(R)-AS-1 (EAAT2 PAM)

货号: PC-49277Not For Human Use, Lab Use Only.

(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.

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生物&药学活性

(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.

物理化学性质&存储条件

分子量	260.293
分子式	C14H16N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)- N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide

参考文献

1. Michał Abram, et al. J Med Chem. 2022 Aug 19. doi: 10.1021/acs.jmedchem.2c00534.

(R)-AS-1 (EAAT2 PAM)

生物&药学活性

物理化学性质&存储条件

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(R)-AS-1 (EAAT2 PAM)

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物理化学性质&存储条件

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