(R)-9bMS | Ack1 inhibitor | ProbeChem Biochemicals

Chemical Structure : (R)-9bMS

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(R)-9bMS ((R)-9b methanesulfonate)

货号: PC-70151Not For Human Use, Lab Use Only.

(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.

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生物&药学活性

(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
(R)-9b also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src.
(R)-9b potently suppresses proliferation of human cancer cell lines with IC50 <2 uM.
(R)-9b exhibits considerable stability in human plasma and a long half-life.

物理化学性质&存储条件

分子量	499.027
分子式	C21H31ClN6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-chloro-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4-diamine methanesulfonate

参考文献

1. Mahajan K, et al. Cancer Cell. 2017 Jun 12;31(6):790-803.e8.

2. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983.

3. Lawrence HR, et al. J Med Chem. 2015 Mar 26;58(6):2746-63.

(R)-9bMS ((R)-9b methanesulfonate)

生物&药学活性

物理化学性质&存储条件

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(R)-9bMS ((R)-9b methanesulfonate)

生物&药学活性

物理化学性质&存储条件

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