(-)-GSK598809 | D3 receptor antagonist | Probechem Biochemicals

Chemical Structure : (-)-GSK598809

CAS No.: 863680-46-0

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(-)-GSK598809 (GSK598809)

货号: PC-49576Not For Human Use, Lab Use Only.

GSK598809 (GSK-598809) is a potent, selective dopamine D(3) receptor antagonist with Ki value of 6.2 nM, >100-fold selectivity over D2 receptor.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

GSK598809 (GSK-598809) is a potent, selective dopamine D(3) receptor antagonist with Ki value of 6.2 nM, >100-fold selectivity over D2 receptor.
GSK598809 increased the hemodynamic effect of cocaine on hemodynamics and cardiac function in freely-moving, telemetered dogs.
GSK598809 selectively enhanced neural response during monetary reward anticipation in drug and acohol dependence.

物理化学性质&存储条件

分子量	481.51
分子式	C22H23F4N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-((3-((1S,5R)-1-(2-fluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-3-yl)propyl)thio)-4-methyl-4H-1,2,4-triazol-3-yl)-4-methyloxazole

参考文献

1. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.

2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.

3. Mugnaini M, et al. Neuropsychopharmacology. 2013 Jan;38(2):302-12.

(-)-GSK598809 (GSK598809)

生物&药学活性

物理化学性质&存储条件

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(-)-GSK598809 (GSK598809)

生物&药学活性

物理化学性质&存储条件

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