δ-secretase inhibitor 11a (AEP inhibitor CP#11A, AEP-IN-2)

Chemical Structure : δ-secretase inhibitor 11a

CAS No.: 2565572-83-8

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货号: PC-28350Not For Human Use, Lab Use Only.

δ-secretase inhibitor 11a (AEP inhibitor CP#11A) is a potent, selective δ-secretase (Asparagine endopeptidase, AEP, Legumain) inhibitor with IC50 of 10 nM, and binding affinity Kd of 5.5 nM.

规格	价格	库存
2 mg	￥2180	In stock
5 mg	￥3580	In stock
10 mg	￥5280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

δ-secretase inhibitor 11a (AEP inhibitor CP#11A) is a potent, selective δ-secretase (Asparagine endopeptidase, AEP, Legumain) inhibitor with IC50 of 10 nM, and binding affinity Kd of 5.5 nM.
δ-secretase inhibitor 11a (AEP inhibitor CP#11A) blocks δ-secretase in primary neurons, dose-dependently attenuates APP N585 and Tau N368 fragmentation by active AEP.
δ-secretase inhibitor 11a (AEP inhibitor CP#11A) blocks AEP auto-activation via proteolytic cleavage.
δ-secretase inhibitor 11a (AEP inhibitor CP#11A) weakly inhibits caspase-3 with IC50 of 30.2 uM.
Combination of δ-secretase inhibitor 11a and TrkB receptor agonist (CF3CN) synergistically blunts δ-secretase, exhibiting promising therapeutic efficacy in 3xTg AD mouse model.

物理化学性质&存储条件

分子量	363.40
分子式	C14H17N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7-((5-(methylamino)-1,3,4-thiadiazol-2-yl)amino)-4-morpholinobenzo[c][1,2,5]oxadiazol-5-yl)methanol

参考文献

1. Jianming Liao, et al. Neuropharmacology. 2021 Oct 1:197:108737.