β-actin inhibitor C25

Chemical Structure : β-actin inhibitor C25

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货号: PC-26933Not For Human Use, Lab Use Only.

β-actin inhibitor C25 is potent, selective and covalent inhibitor of beta-actin (β-actin), does not target α- or γ-actin, inhibits β-Actin polymerization to disrupt the actin cytoskeleton and lead to cell death in143B cells (IC50=15 nM), selectively and covalently binds to Cys272 in β-actin.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

物理化学性质&存储条件

分子量	400.88
分子式	C22H22ClFN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-6-((4-fluorophenyl)amino)phenyl)-N-(2-(tetrahydro-2H-pyran-4-yl)ethyl)propiolamide

参考文献

1. Chen W, et al. J Med Chem. 2026 May 29. doi: 10.1021/acs.jmedchem.6c00299.