trans CM-414 |CAS:1624792-73-9 Probechem Biochemicals

Chemical Structure : trans CM-414

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trans CM-414 (CM 414;CM414)

货号: PC-60416Not For Human Use, Lab Use Only.

trans CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM).

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1 g		Get quote

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生物&药学活性

trans CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM).
trans CM-414 does not inhibit class IIa HDAC isoforms, MMP-3, MMP-10, and PDE9 (IC50>10 uM), has modest or weak activity for HDAC8/11/10 (IC50=640/550/2400 nM).
trans CM-414 diminishes brain Aβ and pTau levels, increases the inactive form of GSK3β, reverts the decrease in dendritic spine density on hippocampal neurons, and reverses the cognitive deficits in Tg2576 mice.

物理化学性质&存储条件

分子量	439.516
分子式	C23H29N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzyl)-N-hydroxycyclobutane-1-carboxamide, trans-

参考文献

1. Cuadrado-Tejedor M, et al. Neuropsychopharmacology. 2017 Jan;42(2):524-539.

trans CM-414 (CM 414;CM414)

生物&药学活性

物理化学性质&存储条件

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trans CM-414 (CM 414;CM414)

生物&药学活性

物理化学性质&存储条件

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