Yanostat | HDAC3 inhibitor | Probechem Biochemicals

Chemical Structure : Yanostat

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Yanostat (KH16)

货号: PC-20992Not For Human Use, Lab Use Only.

Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM).

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生物&药学活性

Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM).
Yanostat (KH16) is less active against the class I HDAC HDAC8 (IC5-=530 nM) and the class IIB HDAC HDAC6 (IC50=460 nM), and has far weaker activity against the class IV HDAC HDAC11 (IC50=870 nM).
Yanostat (KH16) induces apoptosis of HEL erythroleukemia cells with IC50 of 110 nM, which is significantly more effective than SAHA.
Yanostat (KH16) (100 nM) induces accumulation of the acetylated histones H3 and H4, KH16 causes cell cycle arrest and DNA fragmentation.
Yanostat (KH16) dysregulates apoptosis regulators and modulates autophagy and apoptosis in leukemic cells.

物理化学性质&存储条件

分子量	352.40
分子式	C18H20N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NO)C1=CN=C(N=C1)N(CC2)CCN2CC3=CNC4=C3C=CC=C4

参考文献

1. Fischer MA, et al. J Adv Res. 2023 Jul 17:S2090-1232(23)00197-2.

Yanostat (KH16)

生物&药学活性

物理化学性质&存储条件

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Yanostat (KH16)

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物理化学性质&存储条件

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