YAP activator PY-60 | YAP activator | Probechem Biochemicals

Chemical Structure : YAP activator PY-60

CAS No.: 2765218-56-0

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YAP activator PY-60 (PY-60, PY60)

货号: PC-38304Not For Human Use, Lab Use Only.

YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2).

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2).
PY-60 dose-dependently induced luciferase activity in 293A-TEAD-LUC cells, robustly activateed YAP transcriptional activity in vitro.
PY-60 treatment robustly increased the levels of YAP-controlled transcripts (ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1).
PY-60 promotes YAP-dependent expansion of epidermal keratinocytes in mouse following topical drug administration. Annexin A2 (ANXA2) is a protein that directly associates with YAP at the cell membrane in response to increased cell density.
PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.

物理化学性质&存储条件

分子量	313.375
分子式	C16H15N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-phenyl-N-(3-(thiazol-2-yl)propyl)isoxazole-3-carboxamide

参考文献

1. Shalhout SZ, et al. Nat Chem Biol. 2021 Jul;17(7):767-775.

YAP activator PY-60 (PY-60, PY60)

生物&药学活性

物理化学性质&存储条件

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YAP activator PY-60 (PY-60, PY60)

生物&药学活性

物理化学性质&存储条件

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