V-11-0711 | ChoKα inhibitor | Probechem Biochemicals

Chemical Structure : V-11-0711

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V-11-0711 (V-11 0711)

货号: PC-60863Not For Human Use, Lab Use Only.

V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ.

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生物&药学活性

V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ.
V-11-0711 exhibits excellent selectivity against a panel of 50 kinases.
V-11-0711 impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM.
V-11-0711 also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines.

物理化学性质&存储条件

分子量	421.581
分子式	C27H35NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S)-1-phenyl-1-((1S,4S)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol

参考文献

1. Falcon SC, et al. Oncogenesis. 2013;2:e38.

2. Koch K, et al. Oncotarget. 2016 Nov 8;7(45):73414-73431.

V-11-0711 (V-11 0711)

生物&药学活性

物理化学性质&存储条件

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V-11-0711 (V-11 0711)

生物&药学活性

物理化学性质&存储条件

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