Urabrelimab |CAS:2249722-58-3 Probechem Biochemicals

Chemical Structure : Urabrelimab

CAS No.: 2249722-58-3

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Urabrelimab (Anti-human CD47 mAb, human IgG4 (S228P)-Kappa; SRF-231)

货号: PC-Ab1061Not For Human Use, Lab Use Only.

SRF-231 is fully human mAb for CD47, binds with high affinity to CD47, stimulates phagocytosis and the killing of cancer cells in vitro and has potent anti-tumor activity preclinically, both as monotherapy and in combination settings.disrupts the CD47/SIRPα interaction without causing hemagglutination or RBC phagocytosis. SRF231 exerts antitumor activity in vitro through both phagocytosis and cell death in a manner dependent on the activating Fc-gamma receptor (FcγR), CD32a. In tumor-bearing mic

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1 mg	￥3580	In stock
5 mg	￥7580	In stock
10 mg	￥12800	In stock
100 mg		Get quote

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生物&药学活性

Urabrelimab (SRF-231) is fully human mAb for CD47, binds with high affinity to CD47, stimulates phagocytosis and the killing of cancer cells in vitro and has potent anti-tumor activity preclinically, both as monotherapy and in combination settings.
Urabrelimab (SRF-231) disrupts the CD47/SIRPα interaction without causing hemagglutination or RBC phagocytosis.
Urabrelimab (SRF-231) exerts antitumor activity in vitro through both phagocytosis and cell death in a manner dependent on the activating Fc-gamma receptor (FcγR), CD32a.
In tumor-bearing mice, SRF231 increases tumor macrophage infiltration and induction of the macrophage cytokines, mouse chemoattractant protein 1 and macrophage inflammatory protein 1 alpha.
SRF231 is an investigational fully human IgG4 anti-CD47 antibody that is currently under evaluation in a phase 1 clinical trial.

物理化学性质&存储条件

分子量
分子式	Human IgG4 (S228P)-Kappa
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES	SRF-231; SRF231; anti Leukocyte surface antigen CD47; Cluster of differentiation 47; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer); 2249722-58-3

参考文献

1. 1, Marisa O Peluso, et al. J Immunother Cancer. 2020 Apr;8(1):e000413.

Urabrelimab (Anti-human CD47 mAb, human IgG4 (S228P)-Kappa; SRF-231)

生物&药学活性

物理化学性质&存储条件

参考文献

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Urabrelimab (Anti-human CD47 mAb, human IgG4 (S228P)-Kappa; SRF-231)

生物&药学活性

物理化学性质&存储条件

参考文献

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