Tpl2-2 | Tpl2/MAP3K8 inhibitor | Probechem Biochemicals

Chemical Structure : Tpl2-2

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Tpl2-2 (TPL2 Kinase Inhibitor II)

货号: PC-22729Not For Human Use, Lab Use Only.

Tpl2-2 (TPL2 Kinase Inhibitor II) is a cell-permeable naphthyridine-cyclohexyl Tpl2-1 analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 =160 nM).

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生物&药学活性

Tpl2-2 (TPL2 Kinase Inhibitor II) is a cell-permeable naphthyridine-cyclohexyl Tpl2-1 analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 =160 nM).
Tpl2-2 shows little activity (IC50 >20 μM) against EGFR, Src, MEK, p38, PKA, PKC, or S6.
Tpl2-2 blocks LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 μM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).

物理化学性质&存储条件

分子量	390.49
分子式	C22H26N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,7-Naphthyridine-3-carbonitrile, 4-(cycloheptylamino)-6-[(3-pyridinylmethyl)amino]-, hydrate (1:1)

参考文献

1. Neelu Kaila, et al. Bioorg Med Chem. 2007 Oct 1;15(19):6425-42.

Tpl2-2 (TPL2 Kinase Inhibitor II)

生物&药学活性

物理化学性质&存储条件

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Tpl2-2 (TPL2 Kinase Inhibitor II)

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物理化学性质&存储条件

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