Tasisulam |CAS:519055-62-0 Probechem Biochemicals

Chemical Structure : Tasisulam

CAS No.: 519055-62-0

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Tasisulam (LY-573636, LY573636)

货号: PC-62313Not For Human Use, Lab Use Only.

Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
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1 g		Get quote

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生物&药学活性

Tasisulam (LY-573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.
Tasisulam (LY-573636) shows antiproliferative effect against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines.
Tasisulam (LY-573636) promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation.
Tasisulam (LY-573636) causes aberrant pre-mRNA splicing.

物理化学性质&存储条件

分子量	415.1
分子式	C11H6BrCl2NO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro-benzamide

参考文献

1. Meier T, et al. Mol Cancer Ther. 2011 Nov;10(11):2168-78.

2. Haritunians T, et al. Oncol Rep. 2008 Nov;20(5):1237-42.

3. Han T, et al. Science. 2017 Apr 28;356(6336). pii: eaal3755.

Tasisulam (LY-573636, LY573636)

生物&药学活性

物理化学性质&存储条件

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Tasisulam (LY-573636, LY573636)

生物&药学活性

物理化学性质&存储条件

参考文献

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